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| Tamsulosin (rINN) (IPA: [tæm'sulos?n, tæmsu'los?n, ]) is an a1a-selective alpha blocker used in the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin was developed by Yamanouchi Pharmaceuticals (now part of Astellas Pharma) and is marketed by various companies under licence, including Boehringer-Ingelheim and CSL. As of 2006, tamsulosin hydrochloride extended-release tablets are marketed under the trade name Flomaxtra. It was formerly marketed as modified-release capsules under the trade name Flomax Drug class and mechanism : Tamsulosin is a drug applied for the treatment of men who suffer from benign prostatic hyperplasia (BPH) and have difficulty with urination. In men, the canal which carries urine from the bladder to the penis (called the urethra) goes through the prostate gland. At elderly men, the prostate gland extends, and the muscle cells in the prostate gland and the neck of the bladder (which control the flow of urine) tighten. Problems with urination arise owing to the combination of enlargement and tightening of muscles which compresses the urethra and obstructs the flow of urine from the bladder. Normally the tightening or contraction of the muscle cells is supervised by nerves. Tightening of the muscle cells is controled by one type of nerve called the alpha adrenergic nerves. These nerves release a chemical compound similar to epinephrine (adrenalin). Tamsulosin causes a relaxation of the the muscles by inhibiting the effects of this chemical on them. This reduces a barrier to passage of urine. Another drugs which inhibite alpha adrenergic nerves throughout the body are used for the treatment of diseases of the heart, blood vessels, and prostate for example, prazosin (Minipress), terazosin (Hytrin), doxazosin (Cardura), and alfuzosin (Uroxatral). Having the minimal effect on alpha adrenergic nerves receptors elsewhere in the body, tamsulosin is more active against the alpha adrenergic nerves of the prostate and bladder neck, that's why tamsulosin causes fewer side effects than other alpha adrenergic blocking drugs, especially in lowering of blood pressure. In case of therapy by tamsulosin doses can be optimum from the begining while treatment by other alpha adrenergic blocking drugs need to be started at lower doses to minimize the side effects. Tamsulosin was approved by the FDA in 1997 Prescribed for : Tamsulosin is applied for the treatment men's urinating problems caused by BPH. Dosing : Tamsulosin should be accepted once a day after a meal because empty stomach promotes greater mastering of the medicine. This can cause the greater effect and potentially lower pressure of blood. Drug Integration: There have been no reports about drug interactions with tamsulosin. No important interactions were noted during acception tamsulosin with atenolol (Tenormin), enalapril (Vasotec), and nifedipine (Adalat; Procardia). Pregensy : This drug is used only for men. However, animal studies have not demonstrated any risk to the fetus. There are no adequate studies in pregnant women Side effects: Tamsulosin is a well tolerated medicine.
In rare cases tamsulosin can cause a drop in blood pressure, rarely
resulting in dizziness or fainting. Other reported side effects
include headache, dizziness, nasal congestion, and palpitations.
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